Healthy and Slim

Perfect Body

Toxins leaking from the gut ‘are damaging fat cells and driving weight gain’

Fragments of bacteria leaking into the body from the gut are damaging fat cells and driving weight gain, research suggests.

Scientists at Nottingham Trent University have found that these microbe fragments, known as endotoxins, are able to enter the blood stream and directly affect how well fat cells function.

The researchers said their findings, recently published in the journal BMC medicine, help shed light on how endotoxins may drive obesity and associated disease such as type 2 diabetes.

They also added that weight loss interventions such as bariatric surgery “can reverse the damage our gut can pose to our fat cells, which ultimately will have a major impact on our health”.

Endotoxins are toxic substances present inside bacterial cell walls and released when it ruptures or disintegrates.

In a healthy gut, endotoxins are part of the lifecycle of microbes that play a key role in overall human health.

In obese people, the gut barrier is more fragile and can become leaky, allowing endotoxins into the blood and, consequently, other parts of the body.

For the study, the researchers assessed 156 people, 63 of whom were classed as obese.

Their aim was to understand how endotoxins played a role in increasing the risk of obesity and type 2 diabetes.

The team collected blood and fat samples from the participants, which also included people with obesity who underwent bariatric surgery.

They examined two types of fat cells: white fat cells, which store energy, and brown-like fat cells, which use energy and are associated with metabolic activity.

They found that white fat cells derived from those with obesity were less likely to transform into brown-like fat cells, compared with fat cells from lean individuals.

The researchers said this is likely to be due to the higher levels of endotoxins found in the

Read the rest